There are some injuries and ailments that you may suffer from throughout your life that require a little more care than others. When these injuries and ailments become chronic and start affecting your every day life, you might require the expertise of pain management specialists to get over it. These health care professionals can come from a number of different specialties, but all have one dedicated purpose: to discover the cause of your pain and alleviate it in the most effective way possible.
Greek Artist Petros Vrellis is a big admirer of Vincent Van Gogh, which prompted him to produce an interactive version of Starry Night. It took him a patience-sapping six months to produce the original PC version, where finger swipes redirect the painter's famous daubs into a light and sound show. Of course, there was such a clamor from users all desperate to have a go, that he managed to produce an iPad app in a little under a month. Now you can pick it up from the App Store at the source link, or head on past the break to see this new version in action (you really do have to see it).
Vanderbilt-Ingram Cancer Center researchers have identified a new population of intestinal stem cells that may hold clues to the origin of colorectal cancer.
This new stem cell population, reported March 30 in the journal Cell, appears to be relatively quiescent (inactive) ? in contrast to the recent discovery of intestinal stem cells that multiply rapidly ? and is marked by a protein, Lrig1, that may act as a "brake" on cell growth and proliferation.
The researchers have also developed a new and clinically relevant mouse model of colorectal cancer that investigators can now use to better understand where and how the disease arises, as well as for probing new therapeutic targets.
Colorectal cancer is the second leading cause of cancer deaths in the United States. These tumors are thought to arise from a series of mutations in intestinal stem cells, which are long-lived, self-renewing cells that gives rise to all cell types in the intestinal tract.
For more than 30 years, scientists believed that intestinal stem cells were primarily quiescent, proliferating only rarely in order to protect the tissue against cancer. Then, in 2007, researchers reported finding a population of intestinal stem cells (marked by the molecule Lgr5) that were highly proliferative.
Those findings "really changed the way we think about intestinal stem cells," said Robert Coffey, Jr., M.D., Ingram Professor of Cancer Research, co-chair of Vanderbilt's Epithelial Biology Center and senior author on the study.
"It came to so dominate the field that it raised the question about whether quiescent stem cells even exist?and that's where we enter into the picture."
Coffey's lab studies the epidermal growth factor (EGF) signaling pathway ? which includes a family of receptors known as ErbBs ? and its role in cancers of epithelial tissues, like the intestinal tract.
Postdoctoral fellow Anne Powell, Ph.D., led the recent experiments showing that Lrig1, a molecule that regulates ErbB activity, is present in intestinal cells that have the qualities of stem cells (self-renewal, and the ability to produce all the cells of the intestine).
"Essentially, what we show is that the Lrig1-expressing cells are stem cells and they are largely quiescent," Powell said. "We also show that they're distinct from the Lgr5-expressing stem cells that had become a sort of 'hallmark' stem cell population?with different gene expression profiles and different proliferative status."
They also showed that Lrig1 is not only a marker of intestinal stem cells, but also acts as a tumor suppressor and inhibits the growth and proliferative signals of the ErbB family ? acting as a sort of "brake" on cell proliferation that can lead to cancer.
Postdoctoral fellow Yang Wang, Ph.D., eliminated Lrig1 in mice and showed that nearly all of those mice developed intestinal tumors, providing further evidence suggesting that Lrig1 functions as a tumor suppressor.
The findings underscore the importance of ErbB signaling in the behavior of intestinal stem cells from which colorectal cancer may arise.
Most exciting, said Coffey, is that the mouse model his lab has generated as a part of these studies is one of the only mouse models to develop tumors in section of the intestines where most human tumors develop: the colon. One additional advantage of this model, in contrast to others, is that the tumors develop quickly and can be easily monitored with endoscopy, which will make it easier to assess how therapeutic interventions are working.
"We are fairly confident that this will be the 'go-to' model to study colon cancer in mice for the foreseeable future," Coffey said.
###
Vanderbilt University Medical Center: http://www.mc.vanderbilt.edu/npa
Thanks to Vanderbilt University Medical Center for this article.
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Home > Features > Brammo selects Sheffield Financial for retail financing
March 29, 2012 Filed under Features, News
Brammo, Inc. announced it has signed an agreement with Sheffield Financial of North Carolina to provide industry-leading motorsports retail financing through Brammo dealers in all 50 states.
?Sheffield Financial has a strong commitment to customer service that will be greatly appreciated by anyone who wants to ride a Brammo electric motorcycle,? said Craig Bramscher, CEO and founder of Brammo. ?Sheffield?s timely service and quick credit decisions are unmatched in our industry, and we know that is something Brammo customers will value.?
?With Brammo?s innovative electric battery technology, it is poised to make a major impact on the electric vehicle market. We are pleased to offer finance options to Brammo?s customers,? Sheffield Financial president Jack Snow said.
WASHINGTON (AP) ? A former MF Global executive is refusing to answer lawmakers' questions about more than $1 billion in customer money that vanished in the days before the firm collapsed, invoking her Fifth Amendment right against self-incrimination.
Edith O'Brien, a former assistant treasurer at MF Global, was subpoenaed to testify before the House Financial Services oversight subcommittee hearing about an email she sent in the firm's final days.
The email appears to contradict testimony from Jon Corzine, the firm's then-CEO. It says he ordered the transfer of $200 million from a customer account on Oct. 28 to cover an overdraft in the firm's bank account in London.
Corzine testified in December that never directed anyone to use customer funds to fix the overdraft and he wasn't told that customer money was used.
'This is a song about faith,' Lovato says of Unbroken song, for which video premieres next week. By Jocelyn Vena
Demi Lovato Photo: MTV News
Demi Lovato fans won't have to wait too much longer to see the singer's video for her latest single, "Give Your Heart a Break."
The video for Lovato's second Unbroken single will premiere April 2 on E! News. In several teased shots from the clip, a bare-faced Demi looks out from behind a curtain and flirts with her love interest. In another shot, said shirtless love interest returns her tender glances, also from behind a curtain.
"The new music video, I'm basically trying to convince a guy that I didn't break his heart, and we get into a fight and I try to win him over again," she told MTV News. "So I do something special for him at the end of the song."
The video certainly seems like it's going to be sexy, and Lovato commented on having to get romantic with someone she barely knows on set. "It's kind of funny. It's part of the job though. You just try to get through it, but it is kind of awkward at first when you have to act like a couple with someone that you don't know," she said. "He was really sweet, really sweet and really cute."
Recently, Demi opened up a bit more about the track in a video she posted on Twitter. "19-years-old ... sometimes it feels like during that brief time that I've been alive that I've lived through more emotions than people twice my age," she said. "I think that's the reason I sing about love so often in the music I make."
She explained that despite the play on the word "heartbreak" in the title, the song is about the exact opposite. "Last year I began working on a song about a different kind of love," she said. "It's a song about showing someone you love that you're the one right in front of them. This is a song about faith."
Two years ago, I loudly supported the idea that sudden-death overtime places too much emphasis on the coin flip.
And so the adjustment of the postseason overtime rule was a welcome change, even though I still think that, in a playoff game, the team that kicks off should have a chance to match a touchdown scored by the team that has the first possession.
That said, I?m not sure that the elimination of sudden death is the best way to deal with overtime in a regular-season game.
It will make the regular-season games longer, by extending any game in which the team that receives the opening kickoff scores a field goal on the first drive.? Longer games aren?t necessarily an issue in the postseason, since the gap between the starting times is a full 3.5 hours.? In the regular season, it means that some early games will stretch too far into the 4:15 p.m. ET contests and, even worse, that some late-afternoon games will infringe on too much of NBC?s Football Night in America.
Also, longer regular-season games result in more opportunities for player injuries.
Also, there will be more ties, which can wreak havoc on the standings and the playoff possibilities.
Then there?s the fact that last season?s adjustment in the kickoff point, from the 30 to the 35, makes it less likely that the team that wins the coin toss will return the kick to the 40, string together a couple first downs, and win the game on a 50-yard field goal.
So, while I still support the current rules in the postseason, I?m not so sure I like applying the rule to the regular season.
For more analysis of that rule change and the other rules that were, or weren?t changed, he?s the opening segment of Wednesday?s PFT Live.
Fox News pundit Geraldo Rivera has issued an apology - or at least a response - to critics of his recent comments on slain Florida teen Trayvon Martin.
Rivera now infamously said (below) that the unarmed 17-year-old's hoodie was to blame for his death as much as George Zimmerman, who shot him.
Realizing how monumentally offensive, insensitive and just plain wrong that comment was, Rivera is now walking back the statement ... partially.
Rivera is standing by his message, and saying that while others took it as pure flame-fanning, he saw it more as honest, accurate and a PSA of sorts.
"I apologize to anyone offended by what one prominent black conservative called my 'very practical and potentially lifesaving campaign urging black and Hispanic parents not to let their children go around wearing hoodies,'" he told Politico.
"My own family and friends believe I obscured or diverted attention from the primary fact, which is that an unarmed 17-year-old was shot dead by a man who was never seriously investigated by local police. And if that is true, I apologize."
But not, he continued, because he was incorrect.
"I remain absolutely convinced of what I said about asking for trouble. There's enough trouble for minority boys not to provoke mad responses from paranoid jerk-offs."
That should simmer everyone down. Probably. Maybe. Okay, not really.
The film itself is only part of the movie-going experience. There's also the smell of fresh popcorn, the hushed murmer of the crowd as the lights go down, the smell of the sea air, the gentle lapping of the waves—wait, what? More »
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You are here: Home / Physical Fitness / Develop Muscle Tissues And Then Enhance Fitness With One of These Excellent Tips!
If your focus is on muscle building, then review this article for areas that you may want to emphasize. This may include changes to what you eat and an alternative workout. Figure out where you need to do the most work, and use that as a base from which all results will spring.
To boost muscle tissue inside the most effective way you can, you should warm up ahead of every single exercise routine. As your muscles increase in strength, they will begin to suffer further stress and be more likely to be injured. By warming them up, injury can be prevented. You should never do just about any heavy-lifting until after you have accomplished a few gentle workouts for five to ten minutes, accompanied by a number of mild to moderate sets to get warmed up.
Adults who wish to quickly build muscle can add a creatine supplement to their diet. Creatine gives you more energy, which helps to gain more mass. This has been a significant health supplement for some time with regard to weight training exercise, If you aren?t yet accomplished developing, stay away from all health supplements.
Be sure you take a good look at your body and know your limitations. This will help you to identify your current capabilities and to use those to determine realistic goals. Your body composition, coupled with your weight, will be two primary focuses when you do this evaluation.
Change the order of your exercise routine on a regular basis. Avoid getting too accustomed to a single schedule. If you routinely work on the same muscle group last, they will feel tired every time you exercise them. By simply combining the order one does the actual physical exercises inside your regimen, all of the groups of muscles get worked out equally.
Focus on the ?big three? exercises of squats, bench presses and dead lifts to build muscle quickly. Those are movements that will allow you to achieve fitness more rapidly, and continue to build muscle. Different exercises should be added onto your weight-lifting routine, but you should ensure that these three particular exercises are always done on a regular basis.
It is important to limit the amount of your workouts to three to four times a week. This allows your body time to recover from the workouts. You could injure yourself and negative impact your goals by working out too often.
Cutting out alcohol will help you to build muscle more effectively. A beer here and there, or perhaps a tiny amount of wine is alright, nevertheless, alcohol consumption really should never drank excessively. When you are trying to build muscles it is not a smart idea to intake alcohol.
Plyometric exercises are a great way to build muscle. These types of exercises will let your body develop some fast-twitch muscle fibers, and that will help stimulate any muscle growth. Plyometric exercises work like ballistic moves and must have acceleration. Squat jumps are an example of plyometrics, because as you come up from the squat position, you jump as high as possible with your arms extended toward the ceiling, and as you land, you go into the squat before repeating the jump.
As you have now just read, there is much you can do to increase muscle strength in your body. These tips will give you what you need to know to achieve your muscle building goals. Ensure you make use of the guidelines that you just believe will present you with the greatest results, Mix together a number if that works the best for you. While implying these strategies you can use some variety of fitness exercise equipment like fitness stepper to help improve your workout routine and obtain the end result you want.
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An anonymous reader writes "NASA's Kepler mission has discovered 11 new planetary systems hosting 26 confirmed planets. These discoveries nearly double the number of verified planets and triple the number of stars known to have more than one planet that transits, or passes in front of, the star. Such systems will help astronomers better understand how planets form."
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ScienceDaily (Mar. 24, 2012) ? Scientists have used a laser to create magnetic fields similar to those thought to be involved in the formation of the first galaxies; findings that could help to solve the riddle of how the Universe got its magnetism.
Magnetic fields exist throughout galactic and intergalactic space, what is puzzling is how they were originally created and how they became so strong.
A team, led by Oxford University physicists, used a high-power laser to explode a rod of carbon, similar to pencil lead, in helium gas. The explosion was designed to mimic the cauldron of plasma -- an ionized gas containing free electrons and positive ions -- out of which the first galaxies formed.
The team found that within a microsecond of the explosion strong electron currents and magnetic fields formed around a shock wave. Astrophysicists took these results and scaled them through 22 orders-of-magnitude to find that their measurements matched the 'magnetic seeds' predicted by theoretical studies of galaxy formation.
A report of the research is published in a recent issue of the journal Nature.
'Our experiment recreates what was happening in the early Universe and shows how galactic magnetic fields might have first appeared,' said Dr Gianluca Gregori of Oxford University's Department of Physics, who led the work at Oxford. 'It opens up the exciting prospect that we will be able to explore the physics of the cosmos, stretching back billions of years, in a laser laboratory here on Earth.'
The results closely match theories which predict that tiny magnetic fields -- 'magnetic seeds' -- precede the formation of galaxies. These fields can be amplified by turbulent motions and can strongly affect the evolution of the galactic medium from its early stages.
Dr Gregori said: 'In the future, we plan to use the largest lasers in the world, such as the National Ignition Facility at the Lawrence Livermore National Laboratory in California (USA), to study the evolution of cosmic plasma.'
The experiments were conducted at the Laboratoire pour l'Utilisation de Lasers Intenses laser facility in France.
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The above story is reprinted from materials provided by University of Oxford.
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Journal Reference:
G. Gregori, A. Ravasio, C. D. Murphy, K. Schaar, A. Baird, A. R. Bell, A. Benuzzi-Mounaix, R. Bingham, C. Constantin, R. P. Drake, M. Edwards, E. T. Everson, C. D. Gregory, Y. Kuramitsu, W. Lau, J. Mithen, C. Niemann, H.-S. Park, B. A. Remington, B. Reville, A. P. L. Robinson, D. D. Ryutov, Y. Sakawa, S. Yang, N. C. Woolsey, M. Koenig, F. Miniati. Generation of scaled protogalactic seed magnetic fields in laser-produced shock waves. Nature, 2012; 481 (7382): 480 DOI: 10.1038/nature10747
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
A survey of iPhone shoppers from December last year through February, reveals that 13% had bought their iPhones from Best Buy, while 15% had purchased theirs directly from Apple. Of course, carriers brought in the lion's share of sales; AT&T sold to 32% of those surveyed, Verizon claimed 30%, and Sprint a less-than-impressive 7%. The survey, conducted by Consumer Intelligence Research Partners, also showed that online stores only accounted for 24% of sales, with regular brick-and-mortar establishments taking up the remaining 76%.
Thought all those shattered screens and iPhone 4 backplates would push Apple towards making mobile devices machined from aluminum like its laptops and tablets? Think again, friends, because a newly published patent application from Cupertino indicates the company is considering crafting portable computing devices out of glass. The app claims a "substantially seamless enclosure . . . extruded in its entirety with glass material" so that wireless signals can freely flow to and fro, along with a method for manufacturing such a device. Naturally, this is only an application, and it doesn't say exactly what kind of super-durable glass would make this a desirous design change. So, who knows if we'll ever see an all-glass exterior on an iPhone or iPod, but you can get a more in-depth peek at that potential future at the source link below. You can also get a glance at what'll be Android's new anthem should that glass-filled future come to pass after the break.
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Produce safety future focus of supermarkets, farmers and consumersPublic release date: 20-Mar-2012 [ | E-mail | Share ]
Contact: A'ndrea Elyse Messer 814-865-9481 Penn State
Shoppers will continue to see the Fresh Local Produce sign in supermarkets, but stores will increasingly require growers to show proof of good agricultural practices, according to Penn State's College of Agricultural Sciences researchers.
Good agricultural practices -- GAPs -- are food-safety standards that reduce the risk of on-farm produce contamination, according to Daniel Tobin, a doctoral candidate in Agricultural and Extension Education and the principal investigator in the study. GAPs include recommendations for safe irrigation methods, use of raw and composted animal manure, worker health and hygiene, post-harvest handling practices and traceability procedures.
On-farm, food-safety measures are critical, Tobin noted. The U.S. Centers for Disease Control and Prevention estimates 48 million foodborne illnesses, including 3,000 deaths, occur each year in the United States. Previous research indicates that there is a rising number of reported outbreaks in fresh produce.
For Pennsylvania produce growers to maintain wholesale market opportunities, they will have to put forth substantial effort to comply with and verify their on-farm, food-safety practices, the researchers reported in recent issues of Food Control and the Journal of Extension.
"Growers, therefore, will need GAP training and educational materials," Tobin said. "General training about potential on-farm, food-safety hazards and preventative measures no longer will be adequate. To achieve maximum impact, the curriculum must focus on implementing and documenting GAPs so growers will be prepared to pass a GAP audit.
"In response, supermarkets have been implementing policies that require their fresh produce suppliers to attend training workshops on farm food safety and/or to verify compliance with food-safety standards through fee-based, third-party certification. In TPC an independent, third-party auditor conducts an on-site inspection to determine whether a supplier's practices and procedures comply with a certain set of standards, such as GAPs."
Produce growers who need to verify GAP conformity through third-party compliance can select among several audit agencies. The U.S. Department of Agriculture's Agricultural Marketing Service, in association with state departments of agriculture, offers a voluntary audit program that growers can use to verify on-farm food-safety practices. Private companies also offer audit services, but their GAP standards and documentation requirements can vary from company to company.
The Food Safety Modernization Act, signed into law in early 2011 by President Obama, mandates the Food and Drug Administration to establish mandatory minimum standards, based on known safety risks, for produce growers to implement and document.
To help develop a relevant GAP training curriculum that meets the needs of Pennsylvania growers, Penn State researchers surveyed supermarkets that operate in the state to determine their food-safety policies and practices that affect local produce growers.
Pennsylvania consumers also were surveyed because they help drive demand for produce. The researchers found that consumers are highly concerned about the safety of the produce supply.
"Assessing American consumer perceptions regarding produce safety is particularly important, because those perceptions will allow actors within the supply chain to better meet consumer demand," Tobin said. "Using data collected from Pennsylvania consumers, our study documents how consumer demographics -- and their preferences for specific attributes in fresh produce, such as local, organic and inspected for food safety -- affect their produce-safety perceptions."
Such an analysis provides important information for those seeking to implement practices that reduce the risk of foodborne contamination, Tobin explained. A clearer understanding of consumer produce-safety perceptions and preferences will allow these groups, including growers and supermarkets, to make better-informed decisions regarding their food-safety policies and practices.
###
Also involved in the study were Joan Thomson, professor emerita of agricultural communications; Luke LaBorde, associate professor of food science; and Jessica Bagdonis, doctoral candidate in Agricultural and Extension Education.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Produce safety future focus of supermarkets, farmers and consumersPublic release date: 20-Mar-2012 [ | E-mail | Share ]
Contact: A'ndrea Elyse Messer 814-865-9481 Penn State
Shoppers will continue to see the Fresh Local Produce sign in supermarkets, but stores will increasingly require growers to show proof of good agricultural practices, according to Penn State's College of Agricultural Sciences researchers.
Good agricultural practices -- GAPs -- are food-safety standards that reduce the risk of on-farm produce contamination, according to Daniel Tobin, a doctoral candidate in Agricultural and Extension Education and the principal investigator in the study. GAPs include recommendations for safe irrigation methods, use of raw and composted animal manure, worker health and hygiene, post-harvest handling practices and traceability procedures.
On-farm, food-safety measures are critical, Tobin noted. The U.S. Centers for Disease Control and Prevention estimates 48 million foodborne illnesses, including 3,000 deaths, occur each year in the United States. Previous research indicates that there is a rising number of reported outbreaks in fresh produce.
For Pennsylvania produce growers to maintain wholesale market opportunities, they will have to put forth substantial effort to comply with and verify their on-farm, food-safety practices, the researchers reported in recent issues of Food Control and the Journal of Extension.
"Growers, therefore, will need GAP training and educational materials," Tobin said. "General training about potential on-farm, food-safety hazards and preventative measures no longer will be adequate. To achieve maximum impact, the curriculum must focus on implementing and documenting GAPs so growers will be prepared to pass a GAP audit.
"In response, supermarkets have been implementing policies that require their fresh produce suppliers to attend training workshops on farm food safety and/or to verify compliance with food-safety standards through fee-based, third-party certification. In TPC an independent, third-party auditor conducts an on-site inspection to determine whether a supplier's practices and procedures comply with a certain set of standards, such as GAPs."
Produce growers who need to verify GAP conformity through third-party compliance can select among several audit agencies. The U.S. Department of Agriculture's Agricultural Marketing Service, in association with state departments of agriculture, offers a voluntary audit program that growers can use to verify on-farm food-safety practices. Private companies also offer audit services, but their GAP standards and documentation requirements can vary from company to company.
The Food Safety Modernization Act, signed into law in early 2011 by President Obama, mandates the Food and Drug Administration to establish mandatory minimum standards, based on known safety risks, for produce growers to implement and document.
To help develop a relevant GAP training curriculum that meets the needs of Pennsylvania growers, Penn State researchers surveyed supermarkets that operate in the state to determine their food-safety policies and practices that affect local produce growers.
Pennsylvania consumers also were surveyed because they help drive demand for produce. The researchers found that consumers are highly concerned about the safety of the produce supply.
"Assessing American consumer perceptions regarding produce safety is particularly important, because those perceptions will allow actors within the supply chain to better meet consumer demand," Tobin said. "Using data collected from Pennsylvania consumers, our study documents how consumer demographics -- and their preferences for specific attributes in fresh produce, such as local, organic and inspected for food safety -- affect their produce-safety perceptions."
Such an analysis provides important information for those seeking to implement practices that reduce the risk of foodborne contamination, Tobin explained. A clearer understanding of consumer produce-safety perceptions and preferences will allow these groups, including growers and supermarkets, to make better-informed decisions regarding their food-safety policies and practices.
###
Also involved in the study were Joan Thomson, professor emerita of agricultural communications; Luke LaBorde, associate professor of food science; and Jessica Bagdonis, doctoral candidate in Agricultural and Extension Education.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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Public release date: 20-Mar-2012
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